261-5113-00L Computational Challenges in Medical Genomics (Spring 2020)

This seminar discusses recent relevant contributions to the fields of computational genomics, algorithmic bioinformatics, statistical genetics and related areas. Each participant will hold a presentation and lead the subsequent discussion.

Preparing and holding a scientific presentation in front of peers is a central part of working in the scientific domain. In this seminar, the participants will learn how to efficiently summarize the relevant parts of a scientific publication, critically reflect its contents, and summarize it for presentation to an audience. The necessary skills to succesfully present the key points of existing research work are the same as needed to communicate own research ideas. In addition to holding a presentation, each student will both contribute to as well as lead a discussion section on the topics presented in the class.

The topics covered in the seminar are related to recent computational challenges that arise from the fields of genomics and biomedicine, including but not limited to genomic variant interpretation, genomic sequence analysis, compressive genomics tasks, single-cell approaches, privacy considerations, statistical frameworks, etc. Both recently published works contributing novel ideas to the areas mentioned above as well as seminal contributions from the past are amongst the list of selected papers.


The lecture will be held at ETH in CAB G 57 (link to location). Mondays 13-15.

Course Overview

Date Topic Course Material / Literature
17.02.2020 Introduction Session Slides 01
23.02.2020 No session (Preparation)
02.03.2020 No session (Preparation)
09.03.2020 Alignment and Data Structures TBA
16.03.2020 Compression and Applied ML TBA
23.03.2020 No Session
30.03.2020 Genomic Variation TBA
06.04.2020 RNA-Seq Analysis TBA
13.04.2020 No session (Easter)
20.04.2020 RNA-Seq Analysis TBA
27.04.2020 RNA-Seq Analysis TBA
04.05.2020 Session (backup) TBA
11.05.2020 Session (backup) TBA
18.05.2020 No Session TBA
25.05.2020 No Session TBA


Please use the signup-sheet to choose a paper for presentation. Please use exactly one row and do not remove any names from rows that are already assigned.