261-5112-00L Advanced Approaches for Population Scale Compressive Genomics (Autumn 2018)

Semester Autumn Semester 2018
Lecturers A. Kahles
Periodicity yearly course
Language of instruction English

Abstract
Research in Biology and Medicine have been transformed into disciplines of applied data science over the past years. Not only size and inherent complexity of the data but also requirements on data privacy and complexity of search and access pose a wealth of new research questions.

Objective
This interactive course will explore the latest research on algorithms and data structures for population scale genomics applications and give insights into both the technical basis as well as the domain questions motivating it.

Content
Over the duration of the semester, the course will cover three main topics. Each of the topics will consist of 70-80% lecture content and 20-30% seminar content.

1) Algorithms and data structures for text and graph compression. Motivated through applications in compressive genomics, the course will cover succinct indexing schemes for strings, trees and general graphs, compression schemes for binary matrices as well as the efficient representation of haplotypes and genomic variants.

2) Stochastic data structures and algorithms for approximate representation of strings and graphs as well as sets in general. This includes winnowing schemes and minimizers, sketching techniques, (minimal perfect) hashing and approximate membership query data structures.

3) Data structures supporting encryption and data privacy. As an extension to data structures discussed in the earlier topics, this will include secure indexing using homomorphic encryption as well as design for secure storage and distribution of data.

Prerequisites / Notice
Data Structures & Algorithms

Student seminar
For the student seminar on December 12th, the list of suggested papers can be found here.

Location

The lecture will be held at ETH in CHN D 48 (link to location). Wednesdays 13-15.

Course Overview

Date Topic Course Material
26.09.2018 Lecture: Introduction to the topic and Formalities Lecture Slides 01
03.10.2018 Lecture: String indexing (suffix arrays, BWT, FM-index) Lecture Slides 02
10.10.2018 Lecture: Space-efficient index construction Lecture Slides 03
17.10.2018 Lecture: Rank/select structures, BWT construction, Bi-directional BWT Lecture Slides 04
24.10.2018 Lecture: Variations of BWT (Indexing of trees and graphs, PBWT, gPBWT, generalized compressed suffix arrays) Lecture Slides 05
31.10.2018 Lecture: Genome compression Lecture Slides 06
07.11.2018 Lecture: Alignment-based genome comparison (MUMs, MEMs) Lecture Slides 07
14.11.2018 Lecture: Alignment-free genome comparison (kernels, winnowing, hashing) Lecture Slides 08
21.11.2018 Lecture: Approximate genome representation using filters Lecture Slides 09
28.11.2018 Lecture: Sketching techniques, Cardinality estimation Lecture Slides 10
05.12.2018 Lecture: Homomorphic encryption for bioinformatics Lecture Slides 11
12.12.2018 Lecture: Student seminars; Secure communication for personalized genomics No slides
19.12.2018 Lecture: Recap / Exam prep TBA